Side Effects 10 min readSeptember 24, 2026 Headaches on a GLP-1 Microdose: Why They Happen, How Long They Last, and What the Trials Show
Headache hit 15.2 percent of people on semaglutide in STEP 1, but 10.4 percent on placebo too. Why most GLP-1 headaches trace back to less water, less salt, longer gaps between meals, and the coffee you quietly stopped drinking, when they appear and fade, what the IIH:Pressure trial and a 2025 migraine pilot suggest about brain pressure, and which headaches are warning signs.